Tumor infarction in mice by antibody-directed targeting of tissue factor to tumor neo-vasculature. Huang, H., Molema, G., King, S., Watkins, L., Edgington, T.S., and Thorpe, P.E. Angiostatin induces and sustains dormancy of human primary tumors in mice. O'Reilly, M.S., Holmgren, L., Chen, C., and Folkman, J. Angiogenesis in cancer, vascular, rheumathoid and other disease. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumor growth in vivo. Kim, K.J., Li, B., Winer, J., Armanii, M., Gillett, N., Phillips, H.S., and Ferrara, N. Alfa-v integrins as receptors for tumor targetin by circulating ligands. Pasqualini, R., Koivunen, E., and Ruoslahti, E. Rapid tumor penetration of single-chain Fv and comparison with other immunoglobulin forms. Yokota, T., Milenic, D.E., Whitlow, M., and Schlom, J. Purification of bacterially expressed single chain Fv antibodies for clinical applications using metal chelate chromatography. Nature Medicine 2: 979–984.Ĭasey, J.L., Keep, P.A., Chester, K.A., Robson, L., Hawkins, R.E., and Begent, R.H. Clinical evidence of efficient tumor targeting based on single-chain Fv antibody selected from a combinatorial library. Improved bivalent miniantibodies with identical avidity as whole antibodies produced by high cell density fermentation of Escherichia coli. Pack, P., Kujau, M., Schroeckh, U., Knüpfer, R., Wenderoth, R., Riesenberg, D., and Plückthun, A. High level Escherichia coliexpression and production of a bivalent humanized antibody fragment. Making antibodies by phage display technology. Winter, G., Griffiths, A.D., Hawkins, R.E., and Hoogenboom, H.R.
#Affinity at winter park trial#
Phase I clinical trial using escalating single-dose infusion of chimeric anti-CD20 monoclonal antibody (IDEC-C2B8) in patients with recurrent B-cell lymphoma. Maloney, D.G., Liles, T.M., Czerwinski, D.K., Waldichuk, C., Rosenberg, J., Grillo-Lopez, A., and Levy, R. Prevention of manifest metastasis with monoclonal antibodies: a novel approach to immunotherapy of solid tumors. Intralesional radio-immunotherapy of malignant gliomas. Riva, P., Arista, A., Tison, V., Sturiale, C., Franceschi, G., Spinelli, A. Phase II trial of 131I-B1 (anti-CD20) antibody therapy with autolo-gous stem cell transplantation for relapsed B cell lymphomas. Press, O.W., Eary, J.F., Appelbaum, F.R., Martin, P.J., Nelp, W.B., Glen, S., et al. The promise and pitfalls of monoclonal antibody therapeutics.
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